Article
Gnotobiotic mouse model of phage-bacterial host dynamics in the human gut.
Proceedings of the National Academy of Sciences of the United States of America - 10 Dec 2013
Reyes Alejandro, Wu Meng, McNulty Nathan P, Rohwer Forest L, Gordon Jeffrey I
Abstract excerpt
Bacterial viruses (phages) are the most abundant biological group on Earth and are more genetically diverse than their bacterial prey/hosts. To characterize their role as agents shaping gut microbial community structure, adult germ-free mice were colonized with a consortium of 15 sequenced human bacterial symbionts, 13 of which harbored one or more predicted prophages. One member, Bacteroides cellulosilyticus...
Topics
- Animals
- Bacteroides
- Base Sequence
- Cell Count
- Clustered Regularly Interspaced Short Palindromic Repeats
- DNA Primers
- Feces
- Flow Cytometry
- Gastrointestinal Tract
- Genetic Variation
- Germ-Free Life
- Host-Pathogen Interactions
- Humans