Article
Evolution of E. coli in a mouse model of inflammatory bowel disease leads to a disease-specific bacterial genotype and trade-offs with clinical relevance.
Gut microbes - 1 Dec 2023
Unni Rahul, Andreani Nadia Andrea, Vallier Marie, Heinzmann Silke S, Taubenheim Jan, Guggeis Martina A, Tran Florian, Vogler Olga, Künzel Sven, Hövener Jan-Bernd, Rosenstiel Philip, Kaleta Christoph, Dempfle Astrid, Unterweger Daniel, Baines John F
Abstract excerpt
Inflammatory bowel disease (IBD) is a persistent inflammatory condition that affects the gastrointestinal tract and presents significant challenges in its management and treatment. Despite the knowledge that within-host bacterial evolution occurs in the intestine, the disease has rarely been studied from an evolutionary perspective. In this study, we aimed to investigate the evolution of resident bacteria during...
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