Article

The role of mutational spectrum in the selection against mutator alleles

2019-02-08

Abstract excerpt

Rapidly adapting microbe and cancer cell populations often evolve high mutation rates. Yet, once adaptive opportunity declines, antimutator alleles are expected to take over as a result of indirect selection against deleterious mutations. Theory indicates that the most important determinant of antimutator invasions is the extent of mutation rate reduction. However, inconsistent results from evolution experiments s...

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Literature Corpus work: 81c4a4bc-0736-571e-8cff-f477727290bb
DOI: 10.1101/544031

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