Article

Quantifying the adaptive landscape of commensal gut bacteria using high-resolution lineage tracking

2022-05-15

Abstract excerpt

Gut microbiota can adapt to their host environment by rapidly acquiring new mutations. However, the dynamics of this process are difficult to characterize in dominant gut species in their complex in vivo environment. Here we show that the fine-scale dynamics of genome-wide transposon libraries can enable quantitative inferences of these in vivo evolutionary forces. By analyzing >400,000 lineages across four huma...

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Literature Corpus work: 0070dc3e-e75b-5174-9aa2-4c34cbbb2f5c
DOI: 10.1101/2022.05.13.491573

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