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Article

Epigenetic crosstalk in chronic infection with HIV-1

11 Feb 2020

Abstract excerpt

Human immunodeficiency virus 1 (HIV-1) replicates through the integration of its viral DNA into the genome of human immune target cells. Chronically infected individuals thus carry a genomic burden of virus-derived sequences that persists through antiretroviral therapy. This burden consists of a small fraction of intact, but transcriptionally silenced, i.e. latent, viral genomes and a dominant fraction of...

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PMID: 32047948
DOI: 10.1007/s00281-020-00783-3

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