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Article

Unintegrated HIV-1 DNAs are loaded with core and linker histones and transcriptionally silenced

4 Nov 2019

Abstract excerpt

Upon delivery into the nucleus of the host cell, linear double-stranded retroviral DNAs are either integrated into the host genome to form the provirus or act as a target of the DNA damage response and become circularized. Little is known about the chromatinization status of the unintegrated retroviral DNAs of the human immunodeficiency virus type 1 (HIV-1). In this study, we used chromatin immunoprecipitation to...

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PMID: 31685613
DOI: 10.1073/pnas.1912638116

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