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The Epstein–Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteins

25 Jan 2013

Abstract excerpt

Viral proteins reprogram their host cells by hijacking regulatory components of protein networks. Here we describe a novel property of the Epstein-Barr virus (EBV) nuclear antigen-1 (EBNA1) that may underlie the capacity of the virus to promote a global remodeling of chromatin architecture and cellular transcription. We found that the expression of EBNA1 in transfected human and mouse cells is associated with...

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PMID: 23358825
DOI: 10.1093/nar/gkt032

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