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Article

Genome-wide analysis of histone modifications in latently HIV-1 infected T cells

23 Apr 2014

Abstract excerpt

OBJECTIVES: The transcriptional silencing of HIV type 1 (HIV-1) provirus in latently infected cells is a major hurdle on the pathway to HIV-1 elimination. The epigenetic mechanisms established by histone modifications may affect the transcriptional silencing of HIV-1 and viral latency. A systematic epigenome profiling could be applicable to develop new epigenetic diagnostic markers for detecting HIV-1 latency....

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PMID: 24762674
DOI: 10.1097/qad.0000000000000309

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