Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice.

Nature medicine - 1 Apr 2004

Kieran Dairin, Kalmar Bernadett, Dick James R T, Riddoch-Contreras Joanna, Burnstock Geoffrey, Greensmith Linda

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition in which motoneurons of the spinal cord and motor cortex die, resulting in progressive paralysis. This condition has no cure and results in eventual death, usually within 1-5 years of diagnosis. Although the specific etiol...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Disease Progression
Share to Heat-Shock Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydroxylamines

Share to Mice, Transgenic

Share to Motor Neurons

Share to Superoxide Dismutase

Source

Identifiers

PMID: 15034571
DOI: 10.1038/nm1021

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15034571-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice.PMID 15034571Read ↗

Amplifying the Heat Shock Response Ameliorates ALS and FTD Pathology in Mouse and Human Models.Semantic proximity Read ↗

Amplifying the heat shock response ameliorates ALS and FTD pathology in mouse and human models.Semantic proximity Read ↗

Reversal of cognitive deficits in FUSR521G amyotrophic lateral sclerosis mice by arimoclomol and a class I histone deacetylase inhibitor independent of heat shock protein inductionSemantic proximity Read ↗

Amplifying the heat shock response ameliorates pathology in mouse and human models of ALS and FTD.Semantic proximity Read ↗

Exogenous Delivery of Heat Shock Protein 70 Increases Lifespan in a Mouse Model of Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Dihydropyridine Derivatives Modulate Heat Shock Responses and have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer's Disease.Semantic proximity Read ↗

Impact of histone deacetylase inhibition and arimoclomol on heat shock protein expression and disease biomarkers in primary culture models of familial ALSSemantic proximity Read ↗

A variant of the Hspa8 synaptic chaperone modifies disease in a SOD1G86R mouse model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Modeling Protein Aggregation and the Heat Shock Response in ALS iPSC-Derived Motor NeuronsSemantic proximity Read ↗

Early interneuron dysfunction in ALS: Insights from a mutant sod1 zebrafish modelSemantic proximity Read ↗

A copper chaperone-mimetic polytherapy for SOD1-associated amyotrophic lateral sclerosis.Semantic proximity Read ↗

Hsp27 and Hsp70 administered in combination have a potent protective effect against FALS-associated SOD1-mutant-induced cell death in mammalian neuronal cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.