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Article

Amplifying the Heat Shock Response Ameliorates ALS and FTD Pathology in Mouse and Human Models.

Molecular neurobiology - 1 Dec 2023

Ahmed Mhoriam, Spicer Charlotte, Harley Jasmine, Taylor J Paul, Hanna Michael, Patani Rickie, Greensmith Linda

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are now known as parts of a disease spectrum with common pathological features and genetic causes. However, as both conditions are clinically heterogeneous, patient groups may be phenotypically similar but pathogenically and genetically variable. Despite numerous clinical trials, there remains no effective therapy for these conditions, which,...

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Identifiers

PMID: 37516663
DOI: 10.1007/s12035-023-03509-2
PMCID: PMC10657827

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