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Article

Bidirectional interplay of HSF1 degradation and UPR activation promotes tau hyperphosphorylation

5 Jul 2017

Abstract excerpt

The unfolded protein response (UPR) in the endoplasmic reticulum (ER) and the cytoplasmic heat stress response are two major stress response systems necessary for maintaining proteostasis for cellular health. Failure of either of these systems, such as in sustained UPR activation or in insufficient heat shock response activation, can lead to the development of neurodegeneration. Alleviation of ER stress and...

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PMID: 28678786
DOI: 10.1371/journal.pgen.1006849

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