Article

M102 activates both NRF2 and HSF1 transcription factor pathways and is neuroprotective in cell and animal models of amyotrophic lateral sclerosis

2025-07-18

Abstract excerpt

<title>Abstract</title> <p> M102 is a central nervous system (CNS) penetrant small molecule electrophile which activates <italic>in vivo</italic> the NF-E2 p45-related factor 2 - antioxidant response element (NRF2-ARE) pathway, as well as transcription of heat-shock element (HSE) associated genes. In the TDP-43 <sup>Q331K</sup> transgenic mouse model of ALS dosed subcutaneously at 5mg/kg OD or 2.5mg/kg BD wi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c10e3e5b-770e-55f2-a3b7-17f686c9e87d
DOI: 10.21203/rs.3.rs-6964528/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

M102 activates both NRF2 and HSF1 transcription factor pathways and is neuroprotective in cell and animal models of amyotrophic lateral sclerosisDOI 10.21203/rs.3.rs-6964528/v1Read

M102, a combined NRF2 and HSF-1 activator for neuroprotection in amyotrophic lateral sclerosisSemantic proximity Read

New Statement about NRF2 in Amyotrophic Lateral Sclerosis and Frontotemporal DementiaSemantic proximity Read

Brain-Penetrant NF-κB and NLRP3 Targeting Nanoligomers are Therapeutic in Amyotrophic Lateral Sclerosis (ALS) and Alzheimer’s Disease (AD) Human Organoid and Mouse ModelsSemantic proximity Read

Amplifying the heat shock response ameliorates pathology in mouse and human models of ALS and FTD.Semantic proximity Read

Edaravone activates the GDNF/RET neurotrophic signaling pathway and protects mRNA-induced motor neurons from iPS cellsSemantic proximity Read

Dipeptide Repeat Pathology in C9orf72-ALS Is Associated with Redox, Mitochondrial and NRF2 Pathway ImbalanceSemantic proximity Read

Harnessing the Therapeutic Potential of the Nrf2/Bach1 Signaling Pathway in Parkinson’s DiseaseSemantic proximity Read

RMeDPower2 for Biology: guiding the design, experimental structure and analyses of experiments generating repeated measures datasetsSemantic proximity Read

Amplifying the heat shock response ameliorates ALS and FTD pathology in mouse and human models.Semantic proximity Read

Tofersen in SOD1-associated amyotrophic lateral sclerosis: From molecular mechanisms to regulatory milestones.Semantic proximity Read

[Molecular-targeted therapy for motor neuron disease].Semantic proximity Read

The Nrf2-ARE Pathway: A Valuable Therapeutic Target for the Treatment of Neurodegenerative DiseasesSemantic proximity Read