Article

Coronin 1A facilitates calcium mobilization and promotes astrocyte reactivity in HIV-1 Neuropathogenesis

2021-03-22

Abstract excerpt

<title>Abstract</title> <p>BackgroundIn most neurodegenerative disorders, including neuroAIDS, reactive astrocytes are detrimental to the neuronal population. Calcium and its downstream regulators play a central role in mediating astrocyte reactivity. Coronin 1A, an actin binding protein, majorly reported in hematopoietic cells, regulates cell activity in a calcium-dependent manner, but its role in astrocyte phys...

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Literature Corpus work: 477f57be-26d0-592c-960e-fef24d10f6c9
DOI: 10.21203/rs.3.rs-104465/v3

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