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Article

Protease‐sensitive regions in amyloid light chains: what a common pattern of fragmentation across organs suggests about aggregation

5 Sept 2021

Abstract excerpt

Light-chain (AL) amyloidosis is characterized by deposition of immunoglobulin light chains (LC) as fibrils in target organs. Alongside the full-length protein, abundant LC fragments are always present in AL deposits. Herein, by combining gel-based and mass spectrometry analyses, we identified and compared the fragmentation sites of amyloid LCs from multiple organs of an AL λ amyloidosis patient (AL-55). The...

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PMID: 34482629
DOI: 10.1111/febs.16182

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