Article

Cryo-EM of cardiac AL-224L amyloid reveals shared features in λ6 light chain fibril folds

2025-06-27

Abstract excerpt

<h4>ABSTRACT</h4> In amyloid light chain (AL) amyloidosis, aberrant monoclonal antibody light chains (LCs) deposit in vital organs causing organ damage. Each AL patient features a unique LC. Previous cryogenic electron microscopy (cryo-EM) studies revealed different amyloid structures in different AL patients. How LC mutations influence amyloid structures remains unclear. We report a cryo-EM structure of cardiac...

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Literature Corpus work: 6073d6ba-f340-537a-807b-dadefedb821b
DOI: 10.1101/2025.06.25.661559

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