Article

Neuronal activity inhibits axonal mitochondrial transport in a region-specific manner

2024-06-05

Abstract excerpt

Due to their large scale and uniquely branched architecture, neurons critically rely on active transport of mitochondria in order to match energy production and calcium buffering to local demand. Consequently, defective mitochondrial trafficking is implicated in various neurological and neurodegenerative diseases. A key signal regulating mitochondrial transport is intracellular calcium. Elevated Ca 2+ levels have...

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Literature Corpus work: 7cbf21c5-4349-5c7a-b1ea-15dccf20fa09
DOI: 10.1101/2024.06.04.597338

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