Article

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates

2025-10-07

Abstract excerpt

The endoplasmic reticulum (ER)’s continuous morphology is tightly controlled by ER-shaping proteins, whose genetic or expression defects drive a spectrum of neurodegenerative disorders from Hereditary Spastic Paraplegia to Alzheimer’s disease. Why perturbations in ER morphology manifest specifically in neurons remains unknown. Here, by coupling visualisation of global sub-Hz firing bursts to ER ultrastructural man...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4fa898a9-aee0-51ba-aa8d-83224c460a0f
DOI: 10.1101/2025.10.06.677012

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill RatesDOI 10.1101/2025.10.06.677012Read

How neuronal morphology impacts the synchronisation state of neuronal networksSemantic proximity Read

Deep mapping of the <i>endomembrane system</i> of cerebellar Purkinje neuronsSemantic proximity Read

Hyperexcitability in human <i>MECP2</i> null neuronal networks manifests as calcium-dependent reverberating super burstsSemantic proximity Read

<i>Drosophila</i> SPG12 ortholog, reticulon-like 1, governs presynaptic ER organization and Ca <sup>2+</sup> dynamicsSemantic proximity Read

Modeling reveals human-rodent differences in h-current kinetics influencing resonance in cortical layer 5 neuronsSemantic proximity Read

Identification of neural oscillations and epileptiform changes in human brain organoidsSemantic proximity Read

An update to Hippocampome.org by integrating single-cell phenotypes with circuit function in vivo.Semantic proximity Read

Formation, stability, and competition in dendritic proto-spinesSemantic proximity Read

Presynaptic filopodia form kinapses and modulate membrane mechanics for synchronous neurotransmission and seizure generationSemantic proximity Read

Hypersynchronous iPSC-derived <i>SHANK2</i> neuronal networks are rescued by mGluR5 agonismSemantic proximity Read

The Syncytial Mesh Model: A Mesoscale Control-Field Framework for Scale-Dependent Coherence in the BrainSemantic proximity Read

Quantitative firing pattern phenotyping of hippocampal neuron typesSemantic proximity Read