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Article

Impairment of mitochondrial calcium handling in a mtSOD1 cell culture model of motoneuron disease

22 Jun 2009

Abstract excerpt

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the selective loss of motor neurons (MN) in the brain stem and spinal cord. Intracellular disruptions of cytosolic and mitochondrial calcium have been associated with selective MN degeneration, but the underlying mechanisms are not well understood. The present evidence supports a hypothesis that mitochondria are...

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PMID: 19545440
DOI: 10.1186/1471-2202-10-64

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