Article

Exome sequencing in families with severe mental illness identifies novel and rare variants in genes implicated in Mendelian neuropsychiatric syndromes

2018-04-29

Abstract excerpt

<h4>Introduction</h4> Severe Mental Illnesses (SMI), such as bipolar disorder and schizophrenia, are highly heritable, and have a complex pattern of inheritance. Genome wide association studies detect a part of the heritability, which can be attributed to common genetic variation. Examination of rare variants with Next Generation Sequencing (NGS) may add to the understanding of genetic architecture of SMIs. <h4>M...

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Literature Corpus work: 7cb1a082-7811-500b-8ce6-438ca4f4bc0b
DOI: 10.1101/310821

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