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Article

Large-scale whole-exome sequencing of neuropsychiatric diseases and traits in 350,770 adults.

Nature human behaviour - 1 Jun 2024

Deng Yue-Ting, Wu Bang-Sheng, Yang Liu, He Xiao-Yu, Kang Ju-Jiao, Liu Wei-Shi, Li Ze-Yu, Wu Xin-Rui, Zhang Ya-Ru, Chen Shi-Dong, Ge Yi-Jun, Huang Yu-Yuan, Feng Jian-Feng, Zhu Ying, Dong Qiang, Mao Ying, Cheng Wei, Yu Jin-Tai

Abstract excerpt

While numerous genomic loci have been identified for neuropsychiatric conditions, the contribution of protein-coding variants has yet to be determined. Here we conducted a large-scale whole-exome-sequencing study to interrogate the impact of protein-coding variants on 46 neuropsychiatric diseases and 23 traits in 350,770 adults from the UK Biobank. Twenty new genes were associated with neuropsychiatric diseases...

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PMID: 38589703
DOI: 10.1038/s41562-024-01861-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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