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Genetic insights into childhood-onset schizophrenia: The yield of clinical exome sequencing.

Schizophrenia research - 1 Feb 2023

Alkelai Anna, Greenbaum Lior, Shohat Shahar, Povysil Gundula, Malakar Ayan, Ren Zhong, Motelow Joshua E, Schechter Tanya, Draiman Benjamin, Chitrit-Raveh Eti, Hughes Daniel, Jobanputra Vaidehi, Shifman Sagiv, Goldstein David B, Kohn Yoav

Abstract excerpt

Childhood-onset schizophrenia (COS) is a rare form of schizophrenia with an onset prior to 13 years of age. Although genetic factors play a role in COS etiology, only a few causal variants have been reported to date. This study presents a diagnostic exome sequencing (ES) in 37 Israeli Jewish families with a proband diagnosed with COS. By implementing a trio/duo ES approach and applying a well-established...

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PMID: 36645932
DOI: 10.1016/j.schres.2022.12.033

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