Article

Oligogenic rare variant contributions in schizophrenia and their convergence with genes harbouring <i>de novo</i> mutations in schizophrenia, autism and intellectual disability: Evidence from multiplex families

2019-11-12

Abstract excerpt

Clinical and genetic heterogeneity has been documented extensively in schizophrenia, a common behavioural disorder with heritability estimates of about 80%. Common and rare de novo variant based studies have provided notable evidence for the likely involvement of a range of pathways including glutamatergic, synaptic signalling and neurodevelopment. To complement these studies, we sequenced exomes of 11 multimembe...

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Literature Corpus work: a36f785c-9b9b-5d92-9008-0bf0cf8a5157
DOI: 10.1101/829101

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