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Article

Exome hits demystified: The next frontier.

Asian journal of psychiatry - 1 May 2021

Ithal Dhruva, Sukumaran Salil K, Bhattacharjee Debanjan, Vemula Alekhya, Nadella Ravi, Mahadevan Jayant, Sud Reeteka, Viswanath Biju, Purushottam Meera, Jain Sanjeev

Abstract excerpt

Severe mental illnesses such as schizophrenia and bipolar disorder have complex inheritance patterns, involving both common and rare variants. Whole exome sequencing is a promising approach to find out the rare genetic variants. We had previously reported several rare variants in multiplex families with severe mental illnesses. The current article tries to summarise the biological processes and pattern of...

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PMID: 33892377
DOI: 10.1016/j.ajp.2021.102640

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