Article

Engineering Human Pluripotent Stem Cell Lines to Evade Xenogeneic Transplantation Barriers

2023-06-29

Abstract excerpt

<h4>Summary</h4> Allogeneic human pluripotent stem cell (hPSC)-derived cells and tissues for therapeutic transplantation must necessarily overcome immunological rejection by the recipient. To define these barriers and to create cells capable of evading rejection for preclinical testing in immunocompetent mouse models, we genetically ablated β2m , Tap1 , Ciita , Cd74 , Mica , and Micb to limit expression of...

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Literature Corpus work: 7ca7eb8f-b3a9-5309-a565-53553ae223ce
DOI: 10.1101/2023.06.27.546594

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