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CRISPR-Cas9 immune-evasive hESCs are rejected following transplantation into immunocompetent mice

28 May 2024

Abstract excerpt

Although current stem cell therapies exhibit promising potential, the extended process of employing autologous cells and the necessity for donor–host matching to avert the rejection of transplanted cells significantly limit the widespread applicability of these treatments. It would be highly advantageous to generate a pluripotent universal donor stem cell line that is immune-evasive and, therefore, not restricted...

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PMID: 38863835
DOI: 10.3389/fgeed.2024.1403395

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