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Engineering human pluripotent stem cell lines to evade xenogeneic transplantation barriers

11 Jan 2024

Abstract excerpt

Successful allogeneic human pluripotent stem cell (hPSC)-derived therapies must overcome immunological rejection by the recipient. To build reagents to define these barriers, we genetically ablated β2M , TAP1 , CIITA , CD74 , MICA , and MICB to limit expression of HLA-I, HLA-II, and natural killer (NK) cell activating ligands in hPSCs. Transplantation of these cells that also expressed covalent single chain...

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PMID: 38215755
DOI: 10.1016/j.stemcr.2023.12.003

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