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Concise Review: One Stone for Multiple Birds: Generating Universally Compatible Human Embryonic Stem Cells

2 Jun 2016

Abstract excerpt

With ongoing clinical trials, human embryonic stem cells (hESCs) have shown substantial potential for regenerative medicine. However, due to the mismatch of human leukocyte antigens (HLAs) between hESC-derived allografts and recipients, immunosuppressant regimens must be used to prevent immune rejection of the grafts. Considerable efforts have been devoted to overcoming this hurdle via the derivation and banking...

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PMID: 27251112
DOI: 10.1002/stem.2407

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