Article

Diminished Immune Cell Adhesion in Hypoimmune ICAM-1 Knockout Pluripotent Stem Cells

2024-06-09

Abstract excerpt

Hypoimmune gene edited human pluripotent stem cells (hPSCs) are a promising platform for developing reparative cellular therapies that evade immune rejection. Existing first-generation hypoimmune strategies have used CRISPR/Cas9 editing to modulate genes associated with adaptive (e.g., T cell) immune responses, but have largely not addressed the innate immune cells (e.g., monocytes, neutrophils) that mediate infla...

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Literature Corpus work: 3aeeef8d-e4de-56f4-b421-3ab1d94ae0e1
DOI: 10.1101/2024.06.07.597791

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