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Diminished immune cell adhesion in hypoimmune ICAM-1 knockout human pluripotent stem cells

12 Aug 2025

Abstract excerpt

Gene edited human pluripotent stem cells are a promising platform for developing reparative cellular therapies that evade immune rejection. Existing first-generation hypoimmune strategies have used CRISPR/Cas9 editing to modulate genes associated with adaptive immune responses, but have largely not addressed the innate immune cells, such as neutrophils, that mediate inflammation and rejection processes occurring...

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PMID: 40796566
DOI: 10.1038/s41467-025-62568-2

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