Article
Cytochrome P450 Oxidase 2C Inhibition Adds to ω-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2016
Gong Yan, Fu Zhongjie, Edin Matthew L, Liu Chi-Hsiu, Wang Zhongxiao, Shao Zhuo, Fredrick Thomas W, Saba Nicholas J, Morss Peyton C, Burnim Samuel B, Meng Steven S, Lih Fred B, Lee Kin Sing Stephen, Moran Elizabeth P, SanGiovanni John Paul, Hellström Ann, Hammock Bruce D, Zeldin Darryl C, Smith Lois E H
Abstract excerpt
OBJECTIVE: Pathological ocular neovascularization is a major cause of blindness. Increased dietary intake of ω-3 long-chain polyunsaturated fatty acids (LCPUFA) reduces retinal neovascularization and choroidal neovascularization (CNV), but ω-3 LCPUFA metabolites of a major metabolizing pathway, cytochrome P450 oxidase (CYP) 2C, promote ocular pathological angiogenesis. We hypothesized that inhibition of CYP2C...
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