Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Metabolic reprogramming of the neovascular niche promotes regenerative angiogenesis in proliferative retinopathy

25 Jun 2025

Abstract excerpt

Healthy blood vessels supply neurons to preserve metabolic function. In blinding proliferative retinopathies (PRs), pathological neovascular tufts often emerge in lieu of needed physiological revascularization. Here we show that metabolic shifts in the neovascular niche define angiogenic fate. Fatty acid oxidation (FAO) metabolites accumulated in human and murine retinopathy samples. Neovascular tufts with a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiogenesis and VEGF in Cancer
Share to Cancer, Hypoxia, and Metabolism
Share to Retinal Diseases and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40562775
DOI: 10.1038/s41467-025-60061-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metabolic reprogramming of the neovascular niche promotes regenerative angiogenesis in proliferative retinopathyPMID 40562775Read ↗

Metabolic Reprogramming of the Neovascular Niche Promotes Regenerative Angiogenesis in Proliferative RetinopathySemantic proximity Read ↗

Metabolic Reprogramming of the Neovascular Niche Promotes Regenerative Angiogenesis in Proliferative RetinopathySemantic proximity Read ↗

Metabolism and Vascular Retinopathies: Current Perspectives and Future DirectionsSemantic proximity Read ↗

Angiogenesis and Eye DiseaseSemantic proximity Read ↗

Beyond Genetics: The Role of Metabolism in Photoreceptor Survival, Development and RepairSemantic proximity Read ↗

Single-cell transcriptome analyses reveal microglia types associated with proliferative retinopathySemantic proximity Read ↗

Chronic Hypoxic Signalling Reprograms Metabolism and Alters Redox and Lipid Homeostasis in Rod PhotoreceptorsSemantic proximity Read ↗

Photoreceptor metabolic reprogramming: current understanding and therapeutic implicationsSemantic proximity Read ↗

Single-cell transcriptome reveals diversity of Müller cells with different metabolic-mitochondrial signatures in normal and degenerated maculaSemantic proximity Read ↗

Animal Models of Retinopathy of Prematurity: Advances and Metabolic RegulatorsSemantic proximity Read ↗

Angiogenesis revisited from a metabolic perspective: role and therapeutic implications of endothelial cell metabolismSemantic proximity Read ↗

Erucamide regulates retinal neurovascular crosstalkSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.