Article
Dihydrofolate Reductase/Thymidylate Synthase Fine-Tunes the Folate Status and Controls Redox Homeostasis in Plants.
The Plant cell - 1 Nov 2017
Gorelova Vera, De Lepeleire Jolien, Van Daele Jeroen, Pluim Dick, Meï Coline, Cuypers Ann, Leroux Olivier, Rébeillé Fabrice, Schellens Jan H M, Blancquaert Dieter, Stove Christophe P, Van Der Straeten Dominique
Abstract excerpt
Folates (B9 vitamins) are essential cofactors in one-carbon metabolism. Since C1 transfer reactions are involved in synthesis of nucleic acids, proteins, lipids, and other biomolecules, as well as in epigenetic control, folates are vital for all living organisms. This work presents a complete study of a plant DHFR-TS (dihydrofolate reductase-thymidylate synthase) gene family that implements the penultimate step...
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