Article
Phospho-tuning immunity through Denisovan, modern human and mouse TNFAIP3 gene variants
2019-03-27
Abstract excerpt
Resisting or tolerating microbes are alternative strategies to survive infection, but little is known about the evolutionary mechanisms controlling this balance. Here, genomic analyses of anatomically modern humans, extinct Denisovan hominins, and mice revealed a series of missense variants in the immune response inhibitor A20 (encoded by TNFAIP3 ), substituting non-catalytic residues of the ubiquitin protease do...
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Identifiers and source
- Literature Corpus work
- 7c8035e0-2916-5416-b11b-01c2d626b886
- DOI
- 10.1101/589507