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Article

Mammalian interspecies substitution of immune modulatory alleles by genome editing.

Scientific reports - 22 Feb 2016

Lillico Simon G, Proudfoot Chris, King Tim J, Tan Wenfang, Zhang Lei, Mardjuki Rachel, Paschon David E, Rebar Edward J, Urnov Fyodor D, Mileham Alan J, McLaren David G, Whitelaw C Bruce A

Abstract excerpt

We describe a fundamentally novel feat of animal genetic engineering: the precise and efficient substitution of an agronomic haplotype into a domesticated species. Zinc finger nuclease in-embryo editing of the RELA locus generated live born domestic pigs with the warthog RELA orthologue, associated with resilience to African Swine Fever. The ability to efficiently achieve interspecies allele introgression in one...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26898342
DOI: 10.1038/srep21645
PMCID: PMC4761920

Genes

RELA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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