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Article

A novel missense mutation in TNFAIP3 causes haploinsufficiency of A20.

Cellular immunology - 1 Jan 2022

Jiang Wei, Deng Mengyue, Gan Chun, Wang Li, Mao Huawei, Li Qiu

Abstract excerpt

A20, encoded by TNFAIP3, is an effective anti-inflammatory molecule that plays a crucial role in inhibiting NF-κB signal transmission and is linked to multiple inflammatory diseases. It has been reported that the haploinsufficiency of A20 (HA20) caused by multiple base mutations in TNFAIP3 shows early-onset spontaneous Behçet-like disease. However, the mechanisms by which A20 mutations involved in inflammatory...

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Identifiers

PMID: 34808442
DOI: 10.1016/j.cellimm.2021.104453

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A novel missense mutation in TNFAIP3 causes haploinsufficiency of A20.PMID 34808442Read ↗

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