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Article

Early-life Oxytocin Rescues Hippocampal Synaptic Plasticity and Episodic Memory in a Mouse Model of Fragile X Syndrome

2024-12-21

Abstract excerpt

<h4>ABSTRACT</h4> Cognitive disabilities including impairments to episodic memory are debilitating features of autism spectrum disorder (ASD). Here we report that early-life treatment with oxytocin (OXT) fully restores episodic memory and associated synaptic plasticity in a rodent model of an ASD. Fmr1 -knockout (KO) mice -- which mimic the single gene mutation in Fragile X Syndrome -- failed to encode three bas...

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Literature Corpus work
7c46088e-6566-5cb9-8603-121426f9a3a6
DOI
10.1101/2024.12.20.629802
Open publication

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Early-life Oxytocin Rescues Hippocampal Synaptic Plasticity and Episodic Memory in a Mouse Model of Fragile X SyndromeDOI 10.1101/2024.12.20.629802
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