Acute, chronic and conditioned effects of intranasal oxytocin in the mu opioid receptor knockout mouse model of autism: social context matters

Abstract excerpt

Autism Spectrum Disorders (ASD) are neurodevelopmental disorders whose diagnosis relies on deficient social interaction and communication together with repetitive behaviours. Multiple studies have highlighted the potential of oxytocin (OT) to ameliorate behavioural abnormalities in animal models and subjects with ASD. Clinical trials, however, yielded disappointing results. Our study aimed at challenging hypothese...

Topics

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• Administration, Intranasal
• Arvicolinae
• Drug Discovery
• Models, Psychological
• Oxytocin
• Receptors, Oxytocin
• Recognition, Psychology
• Social Behavior

Identifiers and source

Literature Corpus work

132f2135-3294-52dc-b178-a43af5dca1d2

DOI

10.1101/2024.03.07.583912