Article

Impaired hippocampal representation of place in the <i>Fmr1</i> -knockout mouse model of Fragile X syndrome

2017-09-20

Abstract excerpt

Fragile X syndrome (FXS) is an X-chromosome linked intellectual disability and the most common genetic cause of autism spectrum disorder (ASD). Building upon demonstrated deficits in neuronal plasticity and spatial memory in FXS, we investigated how spatial information processing is affected in vivo in an FXS mouse model ( Fmr1 -KO). Healthy hippocampal neurons (so-called place cells) exhibit place-related activ...

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Literature Corpus work: 9f764ad1-1770-5b96-944c-ba04165d7e4c
DOI: 10.1101/191775

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