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Article

Chronic bryostatin-1 rescues autistic and cognitive phenotypes in the fragile X mice.

Scientific reports - 22 Oct 2020

Cogram Patricia, Alkon Daniel L, Crockford David, Deacon Robert M J, Hurley Michael J, Altimiras Francisco, Sun Miao-Kun, Tranfaglia Michael

Abstract excerpt

Fragile X syndrome (FXS), an X-chromosome linked intellectual disability, is the leading monogenetic cause of autism spectrum disorder (ASD), a neurodevelopmental condition that currently has no specific drug treatment. Building upon the demonstrated therapeutic effects on spatial memory of bryostatin-1, a relatively specific activator of protein kinase C (PKC)ε, (also of PKCα) on impaired synaptic...

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Source

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Identifiers

PMID: 33093534
DOI: 10.1038/s41598-020-74848-6
PMCID: PMC7581799

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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