Acute, chronic and conditioned effects of intranasal oxytocin in the mu opioid receptor knockout mouse model of autism: social context matters

Abstract excerpt

<h4>Background: </h4> and Purpose Autism Spectrum Disorders (ASD) are neurodevelopmental disorders whose diagnosis relies on deficient social interaction and communication together with repetitive behaviours. Multiple studies have highlighted the potential of oxytocin (OT) to ameliorate behavioural abnormalities in animal models and subjects with ASD. Clinical trials, however, yielded disappointing results. Our st...

Topics

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• Administration, Intranasal
• Arvicolinae
• Drug Discovery
• Models, Psychological
• Oxytocin
• Receptors, Oxytocin
• Recognition, Psychology
• Social Behavior

Identifiers and source

Literature Corpus work

9c1a7e65-5461-5c5a-bcad-06578dfcd0c0

DOI

10.22541/au.171324592.23865738/v1