Article

Glycogen Depletion as Metabolic Driver of Cancer Cachexia: A Mechanistic Hypothesis Linking Tumor Glucose Demand, Gluconeogenesis, and Muscle Proteolysis

2026-06-24

Abstract excerpt

Cancer cachexia affects 50–80% of patients with advanced malignancy and contributes to 20–30% of cancer-related deaths, yet therapies targeting the predominant cytokine-centric framework have not yielded clinically meaningful, sustained reversal. This persistent therapeutic gap suggests that an upstream driver may have been incompletely characterized. We propose a substrate-level mechanistic hierarchy: (1) the tum...

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Literature Corpus work: 7c40e2be-5909-5c9b-946b-8ca9f20c3187
DOI: 10.20944/preprints202606.1608.v1

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