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Integrating Radiometabolic Modeling with Single-Cell Transcriptomics Reveals Macro_IL1B-Driven Visceral Adipose Remodeling in Early Cancer Cachexia

2026-08-12

Abstract excerpt

<title>Abstract</title> Cancer cachexia is a systemic metabolic syndrome driving an estimated 20–30% of cancer-related deaths, yet early diagnostic biomarkers and actionable therapeutic targets remain elusive. Leveraging CT radiomics and plasma metabolomics in 586 gastric cancer patients, we develop a high-fidelity classifier (AUC = 0.91) that outperforms conventional clinical indices. To mechanistically ancho...

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Literature Corpus work: f758ecf8-4a86-5914-bb89-05eba84c0114
DOI: 10.21203/rs.3.rs-10655249/v1

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