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Article

[18 F]FDG PET unveils a cachexia-specific multiorgan metabolic phenotype and identifies patients with poor prognosis in locally advanced rectal cancer.

European journal of nuclear medicine and molecular imaging - 1 May 2026

Kuang Zhixing, Lin Xiaoqiang, Tu Jiannan, Huang Qizhen, Liao Siqin, Ji Zhongyou, Xu Benhua

Abstract excerpt

PURPOSE: Cancer cachexia is a debilitating syndrome that profoundly impacts survival, yet its systemic metabolic characteristics and prognostic drivers in locally advanced rectal cancer (LARC) remain poorly defined. This study aimed to comprehensively profile the host’s metabolic response in LARC-associated cachexia using [18 F]FDG PET-CT and to evaluate its prognostic implications. METHODS: In this retrospective...

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PMID: 41410873
DOI: 10.1007/s00259-025-07688-z

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