Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hepatic gluconeogenesis and PDK3 upregulation drive cancer cachexia in flies and mice

16 Apr 2025

Abstract excerpt

Cachexia, a severe wasting syndrome characterized by tumour-induced metabolic dysregulation, is a leading cause of death in people with cancer, yet its underlying mechanisms remain poorly understood. Here we show that a longitudinal full-body single-nuclei-resolution transcriptome analysis in a Drosophila model of cancer cachexia captures interorgan dysregulations. Our study reveals that the tumour-secreted...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Mitochondrial Function and Pathology
Share to Nutrition and Health in Aging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40275022
DOI: 10.1038/s42255-025-01265-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hepatic gluconeogenesis and PDK3 upregulation drive cancer cachexia in flies and micePMID 40275022Read ↗

Tumor Cytokine-Induced Hepatic Gluconeogenesis Contributes to Cancer Cachexia: Insights from Full Body Single Nuclei SequencingSemantic proximity Read ↗

Drosophila as a toolkit to tackle cancer and its metabolismSemantic proximity Read ↗

Hepatic ceramide synthesis links systemic inflammation to organelle dysfunction in cancerSemantic proximity Read ↗

Cancer cachexia: lessons from DrosophilaSemantic proximity Read ↗

Concurrent targeting of GSK3 and MEK as a therapeutic strategy to treat pancreatic ductal adenocarcinomaSemantic proximity Read ↗

Tumor loss-of-function mutations in STK11/LKB1 induce cachexia.Semantic proximity Read ↗

PP6 deficiency in mice with KRAS mutation and Trp53 loss promotes early death by PDAC with cachexia-like features.Semantic proximity Read ↗

Systemic muscle wasting and coordinated tumour response drive tumourigenesisSemantic proximity Read ↗

Identification of Anticancer Target Combinations to Treat Pancreatic Cancer and Its Associated Cachexia Using Constraint-Based ModelingSemantic proximity Read ↗

Early adipose tissue wasting in a novel preclinical model of human lung cancer cachexiaSemantic proximity Read ↗

Functional liver genomics identifies hepatokines promoting wasting in cancer cachexiaSemantic proximity Read ↗

Fiber-type vulnerability and proteostasis reprogramming in skeletal muscle during pancreatic cancer cachexiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.