Article

Molecular dissection of HERV-W dependent microglial- and astroglial cell polarization

2024-03-16

Abstract excerpt

<h4>Abstract/Subject</h4> The endogenous retrovirus type W (HERV-W) is a human-specific entity, which was initially discovered in multiple sclerosis (MS) patient derived cells. We initially found that the HERV-W envelope (ENV) protein negatively affects oligodendrogenesis and controls microglial cell polarization towards a myelinated axon associated and damaging phenotype. Such first functional assessments were c...

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Literature Corpus work: 7c186dc0-d156-549f-a8c9-651d88d7b317
DOI: 10.1101/2024.03.15.584408

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