Article

Antibody-mediated rescue of endogenous retrovirus-induced damage in the demyelinated central nervous system

2026-06-12

Abstract excerpt

The human endogenous retrovirus type W (HERV-W) has been identified as a human-specific neuropathological factor that preferentially affects glial cell types in multiple sclerosis (MS). Recent work using transgenic mice with expression of the HERV-W envelope (ENV) protein unveiled that this endogenous retroviral element disrupts myelin repair and polarizes microglial and astroglial cells towards axon-damaging neur...

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Literature Corpus work: ecb776e5-f408-5b71-bc01-b18bfb382e6f
DOI: 10.64898/2026.06.10.731326

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