Article

EZH2 inhibition promotes tumor immunogenicity in lung squamous cell carcinomas

2023-06-08

Abstract excerpt

<h4>ABSTRACT</h4> Two important factors that contribute to resistance to immune checkpoint inhibitors (ICIs) are an immune-suppressive microenvironment and limited antigen presentation by tumor cells. In this study, we examine if inhibition of the methyltransferase EZH2 can increase ICI response in lung squamous cell carcinomas (LSCCs). Our in vitro experiments using 2D human cancer cell lines as well as 3D muri...

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Literature Corpus work: 7be1eba1-247f-53ce-be00-e93b42761de2
DOI: 10.1101/2023.06.06.543919

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