Article

A robust human airway organoid platform enables scalable expansion and trajectory mapping of pulmonary neuroendocrine cells

2026-01-12

Abstract excerpt

<h4>ABSTRACT</h4> Pulmonary neuroendocrine cells (PNECs) are rare chemosensory epithelial cells, facultative stem cells, and a cell-of-origin for neuroendocrine lung cancers, yet the mechanisms governing their differentiation and heterogeneity are poorly understood. Here we establish NEr-fAOs, a human fetal airway organoid platform that robustly enriches PNECs, and identify a cooperative requirement for dual GSK3...

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Literature Corpus work: 7bdaa700-184c-5fd0-9b7b-cf812db536f9
DOI: 10.64898/2026.01.10.698835

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