Article

Distinct airway progenitor cells drive epithelial heterogeneity in the developing human lung

2022-06-14

Abstract excerpt

<h4>ABSTRACT</h4> Recent advances using single cell genomic approaches have identified new epithelial cell types and uncovered cellular heterogeneity in the murine and human lung (1). Here, using scRNA-seq and microscopy we identify and describe a secretory-like cell that is enriched in the small airways of the developing human lung and identified by the unique co-expression of SCGB3A2/SFTPB/CFTR . To place thes...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 83940fe1-0236-5c23-8f43-3338233f4717
DOI: 10.1101/2022.06.13.495813

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Distinct airway progenitor cells drive epithelial heterogeneity in the developing human lungDOI 10.1101/2022.06.13.495813Read

Regionally distinct progenitor cells in the lower airway give rise to neuroendocrine and multiciliated cells in the developing human lungSemantic proximity Read

Single-cell RNA sequencing reveals novel cell differentiation dynamics during human airway epithelium regenerationSemantic proximity Read

A deep lung cell atlas reveals cytokine-mediated lineage switching of a rare cell progenitor of the human airway epitheliumSemantic proximity Read

A single-cell atlas of the human healthy airwaysSemantic proximity Read

Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticitySemantic proximity Read

An integrated single-cell atlas of human lung across the lifespanSemantic proximity Read

Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway EpitheliumSemantic proximity Read

Single Cell RNAseq Reveals A Critical Role of Chloride Channels in Airway DevelopmentSemantic proximity Read

A Single-Cell Atlas of the Human Healthy AirwaysSemantic proximity Read

A single-cell, time-resolved profiling of Xenopus mucociliary epithelium reveals non-hierarchical model of developmentSemantic proximity Read

Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticitySemantic proximity Read

A single-cell, time-resolved profiling of Xenopus mucociliary epithelium reveals nonhierarchical model of developmentSemantic proximity Read