Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticity

Abstract excerpt

While animal models have provided key insights into conserved mechanisms of how the lung forms during development, human-specific developmental mechanisms are not always captured. To fully appreciate how developmental defects and disease states alter the function of the lungs, studies in human lung models are important. Here, we sequenced >150,000 single single-cells from 19 healthy human fetal lung tissues from g...

Topics

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• Congenital Diaphragmatic Hernia Studies
• Neonatal Respiratory Health Research
• Renal and related cancers
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

61de0d75-eb10-58e8-bb8d-1ea4c43f87e8

DOI

10.1101/2023.10.27.564403